Induction of implantation by aromatase inhibitors in ovariectomized mice
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چکیده
منابع مشابه
Review: aromatase inhibitors for ovulation induction.
CONTEXT For the last 40 yr, the first line of treatment for anovulation in infertile women has been clomiphene citrate (CC). CC is a safe, effective oral agent but is known to have relatively common antiestrogenic endometrial and cervical mucous side effects that could prevent pregnancy in the face of successful ovulation. In addition, there is a significant risk of multiple pregnancy with CC, ...
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Background: Aromatase is an enzyme that plays an important role in the development of estrogen-positive breast cancer. Estrogens are essential in human and mainly in women because of their role in sexual development and reproduction. Adverse effects of some aromatase inhibitors increase the need to discover new inhibitors with higher selectivity, lower toxicity and improved potency. In this stu...
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Change in sex ratios for broiler chickens, has many economic benefits of the poultry industry. The gonads in chick embryo at an early stage have the potential to convert to both sexes (male and female). Sexual differentiation is due to aromatase expression in the left gonad in 5-6 days of the embryonic period and the production of estrogen from testosterone. Administration of aromatase inhibito...
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The development of aromatase inhibitors for breast cancer therapy is a result of successful translational research exploring the biochemical effects of different compounds in vivo. Studies assessing plasma oestrogen levels as well as in vivo aromatase inhibition have revealed a consistent difference with respect to biochemical efficacy between the third generation compounds (anastrozole, letroz...
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Endocrine therapies act by either blocking or downregulating the oestrogen receptor or by reducing oestrogen concentrations around and within the cancer cell. In postmenopausal women, oestrogen suppression is achieved by inhibition of the enzyme aromatase by aromatase inhibitors (AIs). Modern AIs (anastrozole, letrozole and exemestane) are more potent than earlier ones and suppress oestradiol l...
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ژورنال
عنوان ژورنال: Reproduction
سال: 1984
ISSN: 1470-1626,1741-7899
DOI: 10.1530/jrf.0.0720345